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Livres
Articles (36)
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Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

Woldt, Estelle, Sebti, Yasmine, Solt, Laura A, Duhem, Christian, Lancel, Steve, Eeckhoute, Jérôme, Hesselink, Matthijs K C, Paquet, Charlotte, Delhaye, Stéphane, Shin, Youseung, Kamenecka, Theodore M,

Journal:

Nature Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 855 KB

english, 2013

Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists

Asteian, Alice, Blayo, Anne-Laure, He, Yuanjun, Koenig, Marcel, Shin, Youseung, Kuruvilla, Dana S., Corzo, Cesar A., Cameron, Michael D., Lin, Li, Ruiz, Claudia, Khan, Susan, Kumar, Naresh, Busby, Sco

Journal:

ACS Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 668 KB

english, 2015

Total Synthesis of (−)-Dictyostatin: Confirmation of Relative and Absolute Configurations

Youseung Shin, Jean-Hugues Fournier, Yoshikazu Fukui, Arndt M. Brückner, Dennis P. Curran

Journal:

Angewandte Chemie

Année:

2004

Langue:

english

Fichier:

PDF, 216 KB

english, 2004

Titelbild: Total Synthesis and Configurational Assignment of (−)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin / Total Synthesis of (−)-Dictyostatin: Confirmation of Relative and Absolute Configurations (Angew. Chem. 35/2004)

Ian Paterson, Robert Britton, Oscar Delgado, Arndt Meyer, Karine G. Poullennec, Youseung Shin, Jean-Hugues Fournier, Yoshikazu Fukui, Arndt M. Brückner, Dennis P. Curran

Journal:

Angewandte Chemie

Année:

2004

Fichier:

PDF, 60 KB

2004

Total Synthesis of (−)-Dictyostatin: Confirmation of Relative and Absolute Configurations

Youseung Shin, Jean-Hugues Fournier, Yoshikazu Fukui, Arndt M. Brückner, Dennis P. Curran

Journal:

Angewandte Chemie International Edition

Année:

2004

Langue:

english

Fichier:

PDF, 217 KB

english, 2004

Cover Picture: Total Synthesis and Configurational Assignment of (−)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin / Total Synthesis of (−)-Dictyostatin: Confirmation of Relative and Absolute Configurations (Angew. Chem. Int. Ed. 35/2004)

Ian Paterson, Robert Britton, Oscar Delgado, Arndt Meyer, Karine G. Poullennec, Youseung Shin, Jean-Hugues Fournier, Yoshikazu Fukui, Arndt M. Brückner, Dennis P. Curran

Journal:

Angewandte Chemie International Edition

Année:

2004

Langue:

english

Fichier:

PDF, 59 KB

english, 2004

ChemInform Abstract: 3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a Novel Class of Farnesyltransferase Inhibitors.

Hyunil Lee, Jinho Lee, Youseung Shin, Wonhee Jung, Jong-Hyun Kim, Kiwon Park, Seonggu Ro, Hyun-Ho Chung, Jong Sung Koh

Journal:

ChemInform

Année:

2002

Fichier:

PDF, 33 KB

2002

Total Synthesis of (-)-Dictyostatin: Confirmation of Relative and Absolute Configurations.

Youseung Shin, Jean-Hugues Fournier, Yoshikazu Fukui, Arndt M. Brueckner, Dennis P. Curran

Journal:

ChemInform

Année:

2004

Fichier:

PDF, 7 KB

2004

Synthesis and Biological Evaluation of (-)-16-Normethyldictyostatin: A Potent Analogue of (-)-Dictyostatin.

Youseung Shin, Jean-Hugues Fournier, Raghavan Balachandran, Charitha Madiraju, Brianne S. Raccor, Guangyu Zhu, Michael C. Edler, Ernest Hamel, Billy W. Day, Dennis P. Curran

Journal:

ChemInform

Année:

2005

Fichier:

PDF, 12 KB

2005

Confirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach

Su-Kyung Lee, Jung Min Kim, Mi-Young Lee, Kwang-Hee Son, Young Il Yeom, Cheol-Hee Kim, Youseung Shin, Jong Sung Koh, Dong Cho Han, Byoung-Mog Kwon

Journal:

International Journal of Cancer

Année:

2006

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2006

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

Youseung Shin, Weiming Chen, Jeff Habel, Derek Duckett, Yuan Yuan Ling, Marcel Koenig, Yuanjun He, Tomas Vojkovsky, Philip LoGrasso, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 493 KB

english, 2009

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors

Romain Noël, Youseung Shin, Xinyi Song, Yuanjun He, Marcel Koenig, Weimin Chen, Yuan Yuan Ling, Li Lin, Claudia H. Ruiz, Phil LoGrasso, Michael D. Cameron, Derek R. Duckett, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 623 KB

english, 2011

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

Yuanjun He, Theodore M. Kamenecka, Youseung Shin, Xinyi Song, Rong Jiang, Romain Noel, Derek Duckett, Weimin Chen, Yuan Yuan Ling, Michael D. Cameron, Li Lin, Susan Khan, Marcel Koenig, Philip V. LoGr

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.52 MB

english, 2011

Synthesis and biological evaluation of (−)-dictyostatin and stereoisomers

Youseung Shin, Jean-Hugues Fournier, Arndt Brückner, Charitha Madiraju, Raghavan Balachandran, Brianne S. Raccor, Michael C. Edler, Ernest Hamel, Rachel P. Sikorski, Andreas Vogt, Billy W. Day, Dennis

Journal:

Tetrahedron

Année:

2007

Langue:

english

Fichier:

PDF, 969 KB

english, 2007

3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors

Hyunil Lee, Jinho Lee, Youseung Shin, Wonhee Jung, Jong-Hyun Kim, Kiwon Park, Seonggu Ro, Hyun-Ho Chung, Jong Sung Koh

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 97 KB

english, 2001

A novel class of highly potent, selective, and non-peptidic inhibitor of ras farnesyltransferase (FTase)

Hyunil Lee, Jinho Lee, Sangkyun Lee, Youseung Shin, Wonhee Jung, Jong-Hyun Kim, Kiwon Park, Kwihwa Kim, Heung Soo Cho, Seonggu Ro, Sunhwa Lee, ShinWu Jeong, Taesaeng Choi, Hyun-Ho Chung, Jong Sung Koh

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 153 KB

english, 2001

Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor

Yeong Soo Oh, Mikyung Yun, Sang Yeul Hwang, Seongwon Hong, Youseung Shin, Koo Lee, Kyung Hee Yoon, Yung Joon Yoo, Dong Soo Kim, Sun Hwa Lee, Yong Hee Lee, Hee Dong Park, Chang Ho Lee, Sang Koo Lee, Sa

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 286 KB

english, 1998

Structural Modification of an Orally Active Thrombin Inhibitor, LB30057: Replacement of the D-Pocket-binding Naphthyl Moiety

Koo Lee, Sang Yeul Hwang, Seongwon Hong, Chang Yong Hong, Chang-Seok Lee, Youseung Shin, Sangsoo Kim, Mikyung Yun, Yung Joon Yoo, Myunggyun Kang, Yeong Soo Oh

Journal:

Bioorganic & Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 343 KB

english, 1998

Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists

Romain Noel, Xinyi Song, Youseung Shin, Subhashis Banerjee, Douglas Kojetin, Li Lin, Claudia H. Ruiz, Michael D. Cameron, Thomas P. Burris, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 3.39 MB

english, 2012

Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation†

Shin, Youseung, Choy, Nakyen, Balachandran, Raghavan, Madiraju, Charitha, Day, Billy W., Curran, Dennis P.

Journal:

Organic Letters

Année:

2002

Langue:

english

Fichier:

PDF, 120 KB

english, 2002

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Solt, Laura A., Wang, Yongjun, Banerjee, Subhashis, Hughes, Travis, Kojetin, Douglas J., Lundasen, Thomas, Shin, Youseung, Liu, Jin, Cameron, Michael D., Noel, Romain

Journal:

Nature

Année:

2012

Langue:

english

Fichier:

PDF, 644 KB

english, 2012

Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα

Youseung Shin, Romain Noel, Subhashis Banerjee, Douglas Kojetin, Xinyi Song, Yuanjun He, Li Lin, Michael D. Cameron, Thomas P. Burris, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 3.64 MB

english, 2012

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Choi, Jang Hyun, Banks, Alexander S., Kamenecka, Theodore M., Busby, Scott A., Chalmers, Michael J., Kumar, Naresh, Kuruvilla, Dana S., Shin, Youseung, He, Yuanjun, Bruning, John B., Marciano, David P

Journal:

Nature

Année:

2011

Langue:

english

Fichier:

PDF, 768 KB

english, 2011

Simplified Discodermolide Analogues: Synthesis and Biological Evaluation of 4- e pi -7-Dehydroxy-14,16-didemethyl-(+)-discodermolides as Microtubule-Stabilizing Agents

Choy, Nakyen, Shin, Youseung, Nguyen, Phu Qui, Curran, Dennis P., Balachandran, Raghavan, Madiraju, Charitha, Day, Billy W.

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 406 KB

english, 2003

Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors

Jin, Zhuang, Khan, Pasha, Shin, Youseung, Wang, Jingyi, Lin, Li, Cameron, Michael D., Lindstrom, Jon M., Kenny, Paul J., Kamenecka, Theodore M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 945 KB

english, 2014

Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors

Jiang, Rong, Frackowiak, Bozena, Shin, Youseung, Song, Xinyi, Chen, Weimin, Lin, Li, Cameron, Michael D., Duckett, Derek R., Kamenecka, Theodore M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 2.53 MB

english, 2013

Enantioselective Total Synthesis of (+)-Gliocladin C

Overman, Larry E., Shin, Youseung

Journal:

Organic Letters

Année:

2007

Langue:

english

Fichier:

PDF, 81 KB

english, 2007

Tubulin Assembly, Taxoid Site Binding, and Cellular Effects of the Microtubule-Stabilizing Agent Dictyostatin †

Madiraju, Charitha, Edler, Michael C., Hamel, Ernest, Raccor, Brianne S., Balachandran, Raghavan, Zhu, Guangyu, Giuliano, Kenneth A., Vogt, Andreas, Shin, Youseung, Fournier, Jean-Hugues, Fukui, Yoshi

Journal:

Biochemistry

Année:

2005

Langue:

english

Fichier:

PDF, 384 KB

english, 2005

Synthesis and Biological Evaluation of (−)-16-Normethyldictyostatin: A Potent Analogue of (−)-Dictyostatin †

Shin, Youseung, Fournier, Jean-Hugues, Balachandran, Raghavan, Madiraju, Charitha, Raccor, Brianne S., Zhu, Guangyu, Edler, Michael C., Hamel, Ernest, Day, Billy W., Curran, Dennis P.

Journal:

Organic Letters

Année:

2005

Langue:

english

Fichier:

PDF, 86 KB

english, 2005

Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation

Shin, Youseung, Choy, Nakyen, Turner, Tiffany R., Balachandran, Raghavan, Madiraju, Charitha, Day, Billy W., Curran, Dennis P.

Journal:

Organic Letters

Année:

2003

Fichier:

PDF, 4 KB

2003

Fluorous Mixture Synthesis of (−)-Dictyostatin and Three Stereoisomers

Fukui, Yoshikazu, Brückner, Arndt M., Shin, Youseung, Balachandran, Raghavan, Day, Billy W., Curran, Dennis P.

Journal:

Organic Letters

Année:

2006

Langue:

english

Fichier:

PDF, 132 KB

english, 2006

Total Synthesis and Biological Evaluation of C16 Analogs of (−)-Dictyostatin

Jung, Won-Hyuk, Harrison, Cristian, Shin, Youseung, Fournier, Jean-Hugues, Balachandran, Raghavan, Raccor, Brianne S., Sikorski, Rachel P., Vogt, Andreas, Curran, Dennis P., Day, Billy W.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 385 KB

english, 2007

An alternate binding site for PPARγ ligands

Hughes, Travis S., Giri, Pankaj Kumar, de Vera, Ian Mitchelle S., Marciano, David P., Kuruvilla, Dana S., Shin, Youseung, Blayo, Anne-Laure, Kamenecka, Theodore M., Burris, Thomas P., Griffin, Patrick

Journal:

Nature Communications

Année:

2014

Langue:

english

Fichier:

PDF, 8.09 MB

english, 2014

Systems Cell Biology Knowledge Created from High Content Screening

Giuliano, Kenneth A., Cheung, Wing S., Curran, Dennis P., Day, Billy W., Kassick, Andrew J., Lazo, John S., Nelson, Scott G., Shin, Youseung, Taylor, D. Lansing

Journal:

Assay and Drug Development Technologies

Année:

2005

Langue:

english

Fichier:

PDF, 659 KB

english, 2005

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

Banerjee, Subhashis, Wang, Yongjun, Solt, Laura A., Griffett, Kristine, Kazantzis, Melissa, Amador, Ariadna, El-Gendy, Bahaa M., Huitron-Resendiz, Salvador, Roberts, Amanda J., Shin, Youseung, Kamenec

Journal:

Nature Communications

Année:

2014

Langue:

english

Fichier:

PDF, 5.60 MB

english, 2014

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

van Marrewijk, Laura M., Polyak, Steven W., Hijnen, Marcel, Kuruvilla, Dana, Chang, Mi Ra, Shin, Youseung, Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.

Journal:

ACS Chemical Biology

Année:

2016

Langue:

english

Fichier:

PDF, 4.28 MB

english, 2016